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KMID : 0617220010120010119
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Duksung Bulletin Phamaceutical Sciences
2001 Volume.12 No. 1 p.119 ~ p.123
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Anti-inflammatory, Analgesic and Antipyretic Activities of Loxoprofen Sodium Given Intramuscularly in Animals
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Hyun, Jin Ee
Li, Da Wei/Lee, Eun Bang/Jeong, Choon Sik
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Abstract
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The evaluation of the anti-inflammatory, analgesic and antipyretic activities of loxoprofen sodium given in intramuscular route was investigated as compared to oral application in rats and mice. The intramuscular ED_50 values of loxoprofen sodium in carrageenan edema and vascular permeability tests are 1.15 and 7.8 ㎎/㎏, respectively, which represent more potent than in case of oral application. Its therapeutic effects in adjuvant arthritis were shown at 6 ㎎/㎏ i.m and 3 ㎎/㎏ p.o. Analgesic effect was shown to be more potent as given intramuscularly. Similar potency of antipyretic effects was shown in both administration routes. Considerably weak gastric damages were observed in intramuscular application.
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